The purpose of this study was to determine the effect of desloratadine treatment on quality of life, daytime functioning, quality of sleep, symptoms, and disease severity in patients who had hives for 6 weeks or longer. Patients took desloratadine for 1 month. Once a week, patients filled out a questionnaire to tell how their hives affected their lives. This questionnaire is called the Dermatology Life Quality Index or DLQI. They also filled out a diary every day to tell how much itching they had, how many hives they had, and how their hives had affected their sleep or daily activities. The patients and doctors rated the patients' overall condition and how much relief patients got from treatment.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
282
desloratadine 5 mg tablets; one tablet orally once a day for 28 days
Change from baseline to day 28 in Dermatology Life Quality Index (DLQI) score
Time frame: Baseline and treatment day 28
Change from Baseline in the DLQI score on treatment days 7, 14, 21
Time frame: Baseline and treatment days 7, 14, 21
Change from Baseline in pruritus, the number of hives, sleep quality, and daily activity impairment on treatment days 7, 14, 21, and 28
Time frame: Baseline and treatment days 7, 14, 21, and 28
Change from Baseline in the Overall Condition of chronic urticaria on treatment days 14 and 28
Time frame: Baseline and treatment days 14 and 28
Percent of subjects who rate their response to therapy as either Complete, Marked, or Moderate Relief on treatment days 14 and 28
Time frame: Treatment days 14 and 28
Evaluation of tolerability and safety by clinical laboratory tests
Time frame: Baseline and treatment day 28
Evaluation of tolerability and safety by adverse events
Time frame: Screening, Baseline, and treatment days 14 and 28
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