Influence of antiviral treatment to the long term prognosis of patients with chronic HBV infection. The aim of antiviral treatment for HBV is to reduce the long term severe complications. In this study, the investigators divided patients with chronic HBV infection into two groups, which start early antiviral treatment and conventional antiviral treatment respectively. All the patients will be followed for ten years. From this study, the investigators want to find out the optimal time for patients with chronic HBV infection to start antiviral treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
600
100mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2years.
600mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2years.
0.5mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2 years.
The Third Affiliated Hospital Of Sun Yat-sen University
Guangzhou, Guangdong, China
RECRUITINGUnnamed facility
Guangzhou, Guangdong, China
RECRUITINGincidence rate of hepatic carcinoma
Time frame: 10 years after treatment
incidence rate of liver cirrhosis
Time frame: 10 years after treatment
incidence rate of fulminant hepatitis
Time frame: 10 years after treatment
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10mg, P.O.,QD, duration: until HBeAg seroconversion for more than 2years.