Study to Assess Safety and Efficacy of Oral Senicapoc Administration on Exercise-induced Asthma

Inclusion Criteria: * Able and willing to give written informed consent to participate in the study as HIPAA authorization; * Clinically acceptable medical history, physical examination, 12 lead ECG, vital signs, and clinical laboratory tests * History of physician-diagnosed asthma according to Global Initiative for Asthma, AND exercise-induced asthma/ bronchoconstriction; * Current treatment for asthma with short-acting inhaled beta-2-agonist ONLY; * Baseline FEV1 \>65% of predicted at Screen Visit 1; * A 20% or greater drop in FEV1 following exercise challenge on at least two separate occasions prior to enrollment; * Non-smoker (refrained from any tobacco usage, or any products containing nicotine, for 6 months prior to Day 1); Exclusion Criteria: * Subject who has experienced any allergic reaction to a drug which, suggests an increased potential for a hypersensitivity to senicapoc (e.g., clotrimazole); * Previous ingestion of senicapoc (ICA-17043) * Pregnant or lactating female; * Condition that might interfere with the absorption, distribution, metabolism, and/or excretion of drugs; subjects who have had any previous gastrointestinal surgery, except appendectomy or cholecystectomy (if performed more than 90 days prior to Screening Visit 1) or a history of clinically significant active cardiovascular, neurologic, endocrine, hepatic, or renal disorders; * Infectious illness, e.g. acute bacterial, acute and chronic parasitic, fungal infection or viral infection within 6 weeks prior to Screening Visit 1 or between Screening Visit 1 and Day 1 (Randomization). * Treatment for conditions other than asthma with systemic corticosteroids within 1 month prior to Visit 1. * Asthma exacerbation having necessitated treatment with inhaled corticosteroids within 6 weeks prior to study Screening Visit 1. * History of severe asthma as defined by use of oral/injectable corticosteroids within the last 3 months and/or more than two bursts in the last year. * Undergoing desensitization therapy unless on a maintenance dose for at least 3 months prior to entry and will continue as such throughout study participation. * History of chronic pulmonary diseases other than asthma. * Considering or scheduled to undergo any surgical procedure during the duration of the study; * Ingestion of any investigational medication within 30 days prior to Screening Visit 1; * A positive plasma alcohol, or urine cotinine test at Screening Visit 1; * Use of the following asthma medications for the stated period prior to Screening Visit 1 and throughout the study: * Oral or parenteral corticosteroids within 3 months prior to Screening Visit 1 * Inhaled corticosteroids (ICS) (e.g., budesonide, fluticasone propionate) within 1 month prior to Screening Visit 1 * long acting beta agonists; leukotriene receptor antagonists; or anti-cholinergic agents (e.g. tiotropium) within the 2 weeks prior to Screening Visit; * Use of antihistamines within 3 days prior to Screening Visit 1; * Has a \>10 pack-year history of smoking; * Hypertension at screen (BP \> 150/90), if deemed by Investigator to be unfit to complete exercise challenge testing; * Screen QTc \> 450 msec or ECG not suitable for QT measurement (e.g., poorly defined termination of T-wave); * After exercise challenge test, subject not recovering to at least 90% of baseline FEV1 following administration of short-acting beta-2-agonist.