Single Daily Dose Rifaximin for the Treatment of Travelers' Diarrhea

Inclusion Criteria: * passage of 3 or more unformed stools in 24 hours plus an additional symptom of enteric disease such as abdominal cramps, nausea, vomiting, or fever; and investigator verification that an unformed stool has been submitted. * is \> 18 years of age * has diarrhea (at least three unformed stools in 24 hrs) plus at least one additional sign or symptom of enteric illness * has acute diarrhea less than 1 week's duration * willingness to provide a diarrhea stool sample * willingness to keep a daily diary for 5 days * signed informed consent Exclusion Criteria: * fever or bloody diarrhea * has taken predictably effective antibiotics in the past week (e.g. quinolones, TMP/SMX, azalide or doxycycline) * is pregnant now, likely to become pregnant, or breast-feeding * has duration of diarrhea of greater than 1 weeks * is allergic to Rifampin or Rifaximin * has a history of significant underlying enteric, pulmonary, cardiac, renal disease, or any CNS disorder * is more than moderately dehydrated