The hippocampus is particularly laden with n-methyl-d-aspartate (NMDA) receptors, and is at the same time one of the most important sites in declarative memory. The rationale of this study is that the NMDA partial agonist D-Cycloserine will promote learning compared to a placebo. On the other hand, the NMDA receptor antagonist Memantine might lead to reduced memory. We believe that the influence of NMDA receptors on memory can be determined via acute co-activation of the NMDA receptors with Cycloserine® (King Pharmaceuticals Ltd, active ingredient: DCycloserin, dose: 250 mg) and Memantine (Axura®, Merz, active ingredient: Memantine, dose: 20 mg)on both a behavioral and functional (fMRI) level.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
120
250 mg, one dose, 60 min prior
250 mg, one dose, 60 min prior
20 mg, one dose, 8 hours prior
20 mg, one dose, 8 hours prior
250 mg, one dose, 60 minutes prior
250 mg, one dose, 60 minutes prior
20 mg, one dose, 8 hours prior
20 mg, one dose, 8 hours prior
Forschungszentrum Juelich GmbH
Jülich, North Rhine-Westphalia, Germany
fMRI during learning task
Time frame: once at drug administration
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