Efficacy and Safety of Lenalidomide for Treatment of Autistic Spectrum Disorders

Inclusion Criteria: * Diagnosis of autistic spectrum disorder as defined by DSM-IV criteria. * Inflammatory CSF and serum markers with elevated level of TNF-Alfa (\> 50pg/ml) or other Cytokine markers such as IL-1, IL-6 or MECP-1, or serum levels of such cytokines greater than 2X normal levels even in absence of CSF markers. or * Patients with interictal epiliptiform EEG changes in the absences of clinical seizures, if CSF inflammatory markers are identified. * Patients will maintain any other baseline medications for autistic problems or EEG treatment as long as on these for prior 6-8 weeks with no dosage changes. Mentally impaired minors require a parent or legal guardian to sign the informed consent. Exclusion Criteria: * -Diagnosis of PPD-NOS and other autism spectrum disorders. * Any serious medical condition, laboratory abnormality, genetic, brain, structural, or psychiatric illness that would prevent the subject from participating. * History of neutropenia, thrombocytopenia or other types of myelosuppression or risk factors for myelosuppression. * History or risk factors for thromboembolic events. * Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study. * Use of any other experimental drug or therapy within 28 days of baseline. * Current use of steroids (e.g. dexamethasone, prednisone), anthracyclines (Doxil, Adriamycin). * Known hypersensitivity to thalidomide. * The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs. * Any prior use of lenalidomide. * Known positive for HIV or infectious hepatitis, type A, B or C or tuberculosis.