Anti-Fibrotic Effects of Losartan In Nash Evaluation Study

Inclusion Criteria: * Adults (both males and females, aged 18+) with steatohepatitis and fibrosis (Kleiner F1-F3), resulting from non-alcoholic fatty liver disease. Exclusion Criteria: * Refusal or inability (lack of capacity) to give informed consent * Average alcohol ingestion \>21 units/week (males) or \>14 units/week (females) * History or presence of Type 1 diabetes mellitus * Haemoglobin A1C \>15.0 * Other causes of chronic liver disease or hepatic steatosis * Any contra-indication to liver biopsy * History of, or planned, gastrointestinal bypass surgery * Hepatocellular carcinoma * Previous liver transplantation * Recent significant weight loss (\>5% total body weight within last 6 months) * Electrolyte disturbance: potassium level outside the normal (local) range * Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>10 x upper limit of normal (ULN) at screening * Recent (within 6 months of baseline liver biopsy and screening visit) or concomitant use of agent known to cause hepatic steatosis (corticosteroids, amiodarone, methotrexate, tamoxifen, tetracycline, high dose oestrogens, valproic acid), or concomitant use of pioglitazone, fluconazole, rifampicin or any drug contra-indicated in the Losartan SmPC * Introduction of metformin, glitazones, a GLP-1 agonist, Vitamin E or C, betaine, s-adenosyl methionine, ursodeoxycholic acid, silymarin, fibrate, pentoxifylline, orlistat, sibutramine or rimonabant within 3 months of baseline liver biopsy and screening visit * Intolerance of angiotensin receptor blockers (ARBs) or presence of multiple allergic reactions to drugs * Use of angiotensin-converting enzyme (ACE) inhibitor or ARB in previous year * Hypotension (systolic \<100, diastolic \<60) * Renal failure (Cr \>130) * Participation in any clinical study of an investigational agent within 30 days or five half-lives of the investigational product, whichever is longer * Presence of clinically relevant cardiovascular, pulmonary, gastrointestinal, renal, hepatic, metabolic, haematological, neurological, psychiatric, systemic, ocular, gynaecologic or any acute infectious disease or signs of acute illness that, in the opinion of the investigator, might compromise the patient's safe participation in the trial * Presence or history of cancer within the past 5 years with exception of adequately treated localized basal cell carcinoma of the skin, in situ cervical carcinoma or solid malignancy surgically excised in toto without recurrence for five years * Women of child-bearing potential not protected by effective contraceptive method of birth control or surgical sterilization and/or who are unwilling or unable to be tested for pregnancy (Pregnancy status will be checked by serum pregnancy testing before initiation of study treatment and by urine pregnancy testing during the trial) * Known allergy or sensitivity to losartan or its excipients (microcrystalline cellulose \[E460\]; lactose monohydrate; pregelitanized maize starch; magnesium stearate \[E572\]; hydroxypropyl cellulose \[E463\]; hypromellose \[E464\])