Changes in mRNA Expression Following Exposure to Naproxen

Inclusion Criteria: * Healthy adult between the ages of 18 and 75 inclusive * Written informed consent prior to undergoing any study procedures * A physical examination which reveals no clinically significant abnormalities * Female subjects of childbearing potential must be taking an acceptable form of contraceptive Exclusion Criteria: * Any mucosal breaks within 2 cm of pyloric channel seen on baseline endoscopy * Any GDU or \>5 gastroduodenal erosions at baseline endoscopy * CXB, CPG, ASA, or NS-NSAID use within the prior 2 weeks * Previous gastrointestinal ulcer * Hypersensitivity or allergy to NSAIDs, ASA, CPG, CXB or other contraindication to taking treatments * Baseline complaints of abdominal pain, nausea, and/or cramping * Any acid blocking medication including antacids, H-2 receptor blocker within the prior 2 weeks, or PPI use within the prior 30 days * Corticosteroids use within the prior 60 days * Any documented bleeding tendency * Has taken warfarin within the prior 60 days * Three or greater alcoholic beverages daily * History of cerebro-vascular event