Efficacy and Safety Study of JNJ-32729463 for Treating Complicated Skin and Skin Structure Infections Compared to Linezolid (Zyvox)

Inclusion Criteria: * Clinical diagnosis of a complicated skin and skin structure infection (cSSSI) including wound infection, deep cellulitis or severe abscess * Women of childbearing potential must agree to use an acceptable form of contraception * Infection site offers ability to obtain a microbiological specimen * Received only 1 dose of any potentially effective systemic antibiotic within 24 hours of beginning study treatment Exclusion Criteria: * History of hypersensitivity or allergic reaction to quinolones or to linezolid * Female and pregnant or breastfeeding or may be pregnant * Chronic or underlying skin condition surrounding the area of infection that may complicate the assessment of response (e.g. atopic dermatitis, eczema, or psoriasis) * Subject has infections with a high cure rate after surgical incision alone after aggressive local skin care * Subject has infection(s) suspected to be caused by Gram-negative rods, anaerobic bacteria or unusual pathogens * Subject has an infection that is expected to require other antifungal, antimycobacterial, or antibacterial agents in addition to study medication Other protocol-specific eligibility criteria may apply