Twelve Month Study Comparing Paliperidone Palmitate and Select Oral Antipsychotics in Adults With Schizophrenia Who Have Been Recently Discharged From an Inpatient Psychiatric Hospital

Inclusion Criteria: * Must be able to understand and sign the informed consent form approved by the Institutional Review Board (IRB) * Must be an outpatient who, following an acute exacerbation of schizophrenia, has been discharged from an inpatient psychiatric hospital within 60 days of screening * Have a current diagnosis of schizophrenia * Have available a designated individual who is likely to have knowledge of the subject's health status and who agrees to let the study site personnel know of changes in the patient's circumstances * Women must be postmenopausal (for at least 2 years), surgically sterile (hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy), abstinent, or if sexually active, be practicing a highly effective method of birth control Exclusion Criteria: * Allergies, hypersensitivity (anaphylaxis-type reaction), or intolerance to risperidone or paliperidone * Actively abusing intravenous drugs * Have a positive urine drug screen test for barbiturates, cocaine, amphetamines, or opiates at screening * have an unstable medical illness * Women who are pregnant or breast-feeding, or planning to become pregnant * Have received injectable antipsychotic treatment within 2 injection cycles prior to screening * Received treatment with clozapine within 3 months of screening * Attempted suicide within 6 months before screening or are at imminent risk of suicide or violent behavior, as clinically assessed by the investigator at time of screening * homeless at time of stuyd consent