Nicotinamide in Hemodialysis Patients With Hyperphosphatemia

Inclusion Criteria: * hemodialysis since 3 months or longer * hemodialysis frequency 3 times weekly * stable phosphate binder dose since one month at screening * serum phosphate level \< 2,42 mmol/l at screening * serum phosphate level \> 1,52 mmol/l after wash out phase * stable treatment with vitamin D analogues since one month at screening Exclusion Criteria: * congestive heart failure * acute bleeding complications * acute myocardial infarction * peptic ulcers * serious liver damage * poorly controlled diabetes * severe visual impairment * uncontrolled high blood pressure * thrombocyte count \< 120/nl * difficulties in swallowing or dysphagia * diminished intestinal motility, megacolon, pseudo- or mechanical obstruction * gastroparesis