The purpose of this study is to compare losartan and benazepril in diabetic patients whose high blood pressure is not controlled by amlodipine and its relationship to statin current use.
Hypertension and diabetes mellitus are important risk factors for cardiovascular morbidity and mortality. Endothelial dysfunction and vascular rigidity are two pathophysiological mechanisms that may explain this relationship. Recent publications showed that both ACEi (angiotensin-converting enzyme inhibitor-induced) and ARB (angiotensin receptor blocker) were capable of improving vascular stiffness and endothelial function, and that these effects occurred despite blood pressure reduction. This study main objective is to assess if ARB (losartan) effects are different from ACEi (benazepril) in endothelial function in patients with diabetes mellitus type 2 and blood pressure not controlled by amlodipine and its relationship to statin current use. Secondary analysis of vascular stiffness will be measured by pulse wave velocity and augmentation index. Echocardiographic parameters, such as indexes of diastolic function, will also be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Patients in this group will receive 20 mg of benazepril per day, orally, during 12 weeks.
Patients in this group will receive 100 mg of losartan per day, orally, during 12 weeks.
Hospital Universitario Pedro Ernesto
Rio de Janeiro, Rio de Janeiro, Brazil
Endothelial Function
Access endothelial function by brachial flow-mediated vasodilation (FMD) and compare it between groups (losartan and benazepril) and its relationship to current statin use.
Time frame: 12 weeks
Vascular Stiffness
Access vascular stiffness by pulse wave velocity and compare it between groups (losartan and benazepril).
Time frame: 12 weeks.
Systolic Blood Pressure
Compare both groups effects on systolic blood pressure.
Time frame: 12 weeks
Diastolic Blood Pressure
Compare both group effects on diastolic blood pressure.
Time frame: 12 weeks
Vascular Stiffness by Augmentation Index
Estimate vascular stiffness by measuring augmentation index and compare it between losartan and benazepril groups.
Time frame: 12 weeks
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