Eszopiclone for the Treatment of Posttraumatic Stress Disorder

Inclusion Criteria: * Male or female outpatients age 18-65 with a primary diagnosis of PTSD and associated sleep disturbance * Good physical health * Willingness and ability to comply with the requirements of the study protocol Exclusion Criteria: * Women pregnant, lactating, or of childbearing potential not using medically accepted contraception * Concurrent use of other psychotropic medications at least two weeks prior to baseline * Concurrent use of other anti-inflammatory medications or anti-cytokine medications. If used on an as-needed (PRN) basis, subjects may enter the study, but will be excluded from cytokine analyses * Concurrent use of beta-blockers less than one month prior to baseline * Serious medical illness or instability for which hospitalization may be likely within the next year * Seizure disorders with the exception of a history of febrile seizures if they occurred during childhood * Sleep apnea or restless leg syndrome * Concurrent psychotherapy initiated within 3 months of randomization or ongoing psychotherapy of any duration directed specifically toward treatment of PTSD and/or sleep disturbance * Patients with significant suicidal ideation * Current legal actions related to trauma or an ongoing relationship with assailant