The aim of this study is to accelerate the development of vaccine candidates against diarrheal diseases caused by Shigella and Enterotoxigenic Escherichia coli (ETEC). We plan to identify cases of laboratory-proven shigellosis and ETEC-associated diarrhea, to study humoral and cellular immune parameters following natural infections with Shigella and ETEC, and to compare the level of pre-existing local, humoral and cellular immune parameters in cases of shigellosis and ETEC-associated diarrhea and in matched controls.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
330
Stool, blood, urine and saliva samples
Leumit Health Care System
Petach Tikvah, Elad, Israel
Emek Medical Center
Afula, Israel
Hillel Yaffe Medical Center
Hadera, Israel
Lady Davis Carmel Medical Center
Haifa, Israel
Identification of cases of shigellosis and ETEC-associated diarrhea
Stool of patients examined in laboratory and identified as infected with the pathogens
Time frame: Four years
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