Interpersonal Psychotherapy for Treatment Resistant Depression

Hospital de Clinicas de Porto Alegre74 enrolled

Overview

The purpose of this study is to determine whether combination of antidepressant drugs plus interpersonal psychotherapy is superior to antidepressant drugs alone in treatment resistant depression.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Treatment Resistant Depression

Interventions

IPT+ antidepressant drugsOTHER

16 sessions of interpersonal psychotherapy plus antidepressant drugs.

fluoxetineDRUG

Antidepressant drugs, clinician´s free choice oriented by guidelines. Monotherapy or combinations are allowed

sertralineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Primary diagnose of unipolar treatment resistant depression Exclusion Criteria: * Patients diagnose of: bipolar disorder, psychosis, high suicide risk, Intellectual disability, illicit drug dependence. * Currently in or having received psychotherapy in the last 4 weeks

Locations (1)

Federal University of Rio Grande do Sul / Hospital de Clínicas de Porto Alegre (HCPA)

Porto Alegre, Rio Grande do Sul, Brazil

RECRUITING

Outcomes

Primary Outcomes

Hamilton Depression Scale (HAM-D) - continuous

Score change on Hamilton depression scale from baseline to week 19 and to week 24

Time frame: End point week 19 and Week 24

Secondary Outcomes

Beck depression Inventory (BDI)

Score change on Beck depression inventory from baseline to week 19 and to week 24

Time frame: End point week 19 and Week 24

Central Contacts

Livia H Souza, MD

CONTACT

+55 51 98658701 liviahartmanndesouza@gmail.com

Marcelo PA Fleck, PhD

CONTACT

+55 51 33598294 mfleck.voy@terra.com.br

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.