The purpose of the study is to determine whether a diuretic drug called amiloride is capable of increasing renal salt excretion and thereby decrease blood pressure in diabetic patients with kidney disease. Our hypothesis states that amiloride is capable of reducing blood pressure in these patients and thus decrease the cardiovascular risk associated with diabetic kidney disease.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
80
200 mmol NaCl per day given as three meals daily for 4 consecutive days.
Amiloride tablet 20 mg two times daily (morning and afternoon) for two consecutive days.
Cardiovascular and Renal Research
Odense, Denmark
24-hour urinary sodium excretion induced by amiloride
Time frame: Change from baseline urinary sodium excretion at 24 hours after amiloride administration
Office blood pressure measurements
Time frame: Change from baseline office blood pressure at day 4 of salt diet and at 24 hours after amiloride administration
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