Anti-histamines and Methacholine Challenges.

Phase 4CompletedNCT01985789

Don Cockcroft12 enrolled

Overview

The asthmatic airway is identified and studied using inhaled agents such as histamine and methacholine. The use of antihistamines prior to the test will inhibit the test result if histamine is used to cause airway constriction. If using methacholine, this may also be true depending on whether old (e.g. benadryl) or new (e.g. desloratadine) antihistamines are used. This study will look at the effect of old and new antihistamines on inhaled methacholine challenge response in individuals with mild asthma.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

TRIPLE

Enrollment

Conditions

Asthma

Interventions

DiphenhydramineDRUG

cetirizineDRUG

desloratadineDRUG

placeboDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Baseline forced expiratory volume in 1s (FEV1) of 70% or more of predicted * Methacholine provocative concentration causing a 20% fall in FEV1 16mg/ml or less * No respiratory infection or change in allergen exposure for 4 weeks prior to screening and throughout the study * No significant medical co-morbidities * allergy Exclusion Criteria: * pregnant or breastfeeding females * unable to withhold antihistamines, anticholinergics, long acting bronchodilators and combination therapies

Locations (1)

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Outcomes

Primary Outcomes

change in methacholine pc20

Time frame: change from baseline (pre dose) at 2 hours (post dose)

Data from ClinicalTrials.gov

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