Effect of Metamizole (Dipyrone) on Renal Function in Salt-depleted Healthy Subjects

Inclusion Criteria: * Healthy male subjects aged between 18 and 45 years (inclusive) at screening * BMI between 18 and 28 kg/m2 (inclusive) and body weight at least 50 kg at screening. * systolic blood pressure (SBP): 100-140 mmHg, diastolic blood pressure (DBP): 60-90 mmHg and heart rate (HR): 45-90 bpm (inclusive), measured on the leading arm\*, in the supine position at screening. * No clinically significant findings on the physical examination at screening. * 12-lead ECG without clinically relevant abnormalities at screening. * Signed informed consent prior to any study-mandated procedure. * Hematology and clinical chemistry results not deviating from the normal range to a clinically relevant extent at screening. * Ability to communicate well with the investigator and to understand and comply with the requirements of the study. * leading arm right = writing with right hand Exclusion Criteria: * Smoking \> 5 cigarettes per day. * History or clinical evidence of alcoholism or drug abuse within the 3-year period prior to screening. * Loss of ≥ 250 ml of blood within 3 months prior to screening. * Treatment with an investigational drug within 30 days prior to screening. * Previous treatment with any prescribed or over-the-counter (OTC) medication (including herbal medicines such as St John's Wort) within 2 weeks prior to the intended start of the study. * Legal incapacity or limited legal capacity at screening. * Positive results from urine drug screen at screening. * History or clinical evidence of any disease (e.g. GIT-disease: Morbus Crohn, Colitis Ulcerosa, anamnestic gastrointestinal bleeding) and/or existence of any surgical or medical condition, which might interfere with the absorption, distribution, metabolism or excretion of the study drugs, or which might increase the risk for toxicity. * Known hypersensitivity to Aspirin or other NSAIDs or any excipients of the drug formulations. * Known food allergy, which make the adherence to the diet impossible * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol.