To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
furosemide (doubling previous furosemide dose)
metolazone (add 2.5mg qod)
spironolactone (doubling previous spironoalctone dose or add 12.5mg BID if previous non-user)
urine output change
efficacy of diuretics add-on therapy, urine output change
Time frame: from admission to Hospital Day (HOD)#4
serum creatinine change
safety of diuretics add-on therapy, serum creatinine change
Time frame: from admission to HOD#4
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no spironolactone (maintaining previous spironolactone dose or not add spironolactone if previous non-user)