This study will evaluate the imaging characteristics of flortaucipir in subjects with a previous flortaucipir scan in order to assess the rate of change of tau deposition over time.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
44
370 megabecquerel (MBq) IV single-dose
370 megabecquerel (MBq) IV single-dose
positron emission tomography (PET) scan of the brain
Hoag Memorial Hospital
Newport Beach, California, United States
UC Irvine Medical Center
Orange, California, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Center for Clinical Imaging Research, Washington University School of Medicine
St Louis, Missouri, United States
Change in Tau Deposition
Rate of tau deposition change as measured by flortaucipir standardized uptake value ratio (SUVr). For SUVr, a value of 1 signifies no flortaucipir activity above background, values greater than 1 signify increasing flortaucipir activity in the brain.
Time frame: baseline scan and at least 6 months after baseline scan
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