Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant

Inclusion Criteria: 1. Age \< 18 years and \> 1 month (\< 1 month upon approval by Sponsor) 2. Life expectancy \> 10 weeks 3. Patients deemed clinically eligible for allogeneic stem cell transplantation. 4. Patients may have failed prior allograft 5. Patients with life-threatening acute leukemia (high-risk ALL in 1st CR, ALL in 2nd CR, high-risk AML in 1st CR, AML in 2nd CR.) or myelodysplastic syndromes. Morphological CR must be documented and minimal residual disease measurement before transplantation is recommended. 6. Non-malignant disorders deemed curable by allogeneic transplantation: (a) primary immune deficiencies, (b) severe aplastic anemia not responding to immune suppressive therapy, (c) osteopetrosis, (d) selected cases of erythroid disorders such as β0 β0 thalassemia major, sickle cell disease, Diamond-Blackfan anemia, (e) congenital/hereditary cytopenia, including Fanconi Anemia before any clonal malignant evolution (MDS, AML). Note: Subjects will be eligible if they meet either item 5 OR item 6. 7. Lack of suitable conventional donor (HLA identical sibling or HLA phenotypically identical relative or 10/10 unrelated donor evaluated using high resolution molecular typing) or presence of rapidly progressive disease not permitting time to identify an unrelated donor 8. A minimum genotypic identical match of 5/10 is required. 9. The donor and recipient must be identical, as determined by high resolution typing, on at least one allele of each of the following genetic loci: HLA-A, HLA-B, HLA-Cw, HLA- DRB1 and HLA-DQB1. 10. Lansky/Karnofsky score \> 50 11. Signed informed consent by the patient or the patient's parent or guardian for patients who are minors Exclusion Criteria: 1. Greater than active Grade II acute GvHD or chronic extensive GvHD due to a previous allograft at the time of screening 2. Patient receiving an immunosuppressive treatment for GvHD treatment due to a previous allograft at the time of screening 3. Dysfunction of liver (ALT/AST \> 5 times normal value, or bilirubin \> 3 times normal value), or of renal function (creatinine clearance \<30ml/min/1.73m2) 4. Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or left ventricular ejection fraction \< 40%) 5. Current clinically active infectious disease (including positive HIV serology or viral RNA) 6. Serious concurrent uncontrolled medical disorder 7. Pregnant or breast feeding female patient 8. Lack of parents'/guardian's informed consent for children who are minors.