Safety and Efficacy of Oral Febuxostat in Subjects With Gout

Inclusion Criteria: * Hyperuricemia (serum urate ≥8.0 mg/dL) and gout by Chinese Rheumatism Association Criteria; * Renal function defined as a serum creatinine level of \< 2.0 mg/dL and creatinine clearance of \> 20 milliliters per minute (mL/min) by Cockcroft and Gault formula; * No gout flare 2 weeks beforehand during 2-week screening period. Exclusion Criteria: * Pregnancy or lactation; * Concurrent therapy with urate lowering agents, azathioprine, 6-mercaptopurine, thiazide diuretics, or medications containing aspirin (\>325 mg) or other salicylates; * Body Mass Index (BMI) \>50 kilogram per meter²(kg/m²); * A history of active liver disease, or hepatic dysfunction; * A history of bronchial asthma; * A history of renal calculi or thyroid disease; * Secondary gout Joint diseases induced by rheumatoid arthritis, psoriatic arthritis and bone tumor; * Intolerance to allopurinol and Ibuprofen; * Alcohol intake of ≥ 14 drinks/week; * Clinically significant medical condition.