The purpose of this study is to evaluate whether clobazam, brand name Onf®, is more effective as an adjunctive or monotherapy in terminating Epilepsia Partialis Continua (EPC) than either lorazepam and/or clonazepam.
First approved in the United States in 2011 for use in treating Lennox-Gastaut syndrome, clobazam is the only 1, 5-benzodiazepine that is currently approved for clinical use in the United States. In previous clinical trials clobazam has been shown to have a greater efficacy and produce fewer side effects in individuals when it's adverse event profile is compared to the traditional 1,4-benzodiazepines such as diazepam, lorazepam, and clonazepam. As a benzodiazepine, clobazam has been found to have anticonvulsant properties, and structural differences as a 1,5-benzodiazepines that appear to have a broader spectrum of anticonvulsant activity than those found in 1,4-benzodiazepines. In previous reports, clobazam has been seen to be effective in ether terminating or reducing both EPC in particular and partial status epilepticus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
7
Comparison of AED use in Epilepsia Partialis Continua
Comparison of AED use in Epilepsia Partialis Continua
Comparison of AED use in Epilepsia Partialis Continua
Cooper Universtiy Hospital
Camden, New Jersey, United States
Time (measured in minutes) to onset of seizure freedom
Time frame: Within 7 days
Reduction of seizure frequency/minute
Time frame: Within 7 days
Mental status preservation off sedating anticonvulsants as measured by the MoCA© scale
Time frame: Within 37 days
Ambulatory function as measured by the Hauser Ambulation Index
Time frame: Within 37 days
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