A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis.

Inclusion Criteria: 1. Provide written, informed consent prior to all trial-related procedures. Male or female, aged between 18 and 75 years inclusive. 2. Body weight (in light clothing and with no shoes) between 35 and 100 kg, inclusive. 3. Tested at the trial appointed laboratory: M. Tb positive on molecular test (e.g. GeneXpert or Hain) and sputum smear-positive pulmonary TB on direct microscopy for acid-fast bacilli (at least 1+ on the IUATLD/WHO scale. * For DS-TB treatment arms (defined as sensitive to rifampicin based on molecular sensitivity testing), Subjects should be: 1. either newly diagnosed or untreated for at least 3 years after cure from a previous episode (Subject can give a history of cure and previous treatment); AND 2. Previous TB treatment must be discontinued as per exclusion criteria 16. * For MDR-TB treatment arm (defined as resistant to rifampicin based on molecular sensitivity testing), Subjects should be: 1. sensitive to moxifloxacin by molecular sensitivity testing; AND 2. either newly diagnosed or could have previously been treated for DS-TB and/or MDR-TB (\< 7 days of treatment). Previous MDR-TB treatment must be discontinued as per exclusion criteria 17. 4. A chest X-ray picture which in the opinion of the Investigator is compatible with TB. 5. Ability to produce an adequate volume of sputum as estimated from a screening Coached Spot Sputum Sample assessment (estimated 10 ml or more overnight production). 6. Be of non-childbearing potential or using effective methods of birth control, as defined below: Non-childbearing potential: 1. Subject - not heterosexually active or practices sexual abstinence; or 2. Female Subject/sexual partner - bilateral oophorectomy, bilateral tubal ligation and/or hysterectomy or has been postmenopausal with a history of no menses for at least 12 consecutive months; or 3. Male Subject/sexual partner - vasectomised or has had a bilateral orchidectomy minimally three months prior to screening. Effective birth control methods: A double contraceptive method should be used as follows: 1. Double barrier method which can include any 2 of the following: a male condom, diaphragm, cervical cap, or female condom (male and female condoms should not be used together); or 2. Barrier method (one of the above) combined with hormone-based contraceptives or an intra-uterine device for the female Subject/partner; and are willing to continue practicing birth control methods throughout treatment and for 6 months (both male and female Subjects) after the last dose of study medication or discontinuation from study medication in case of premature discontinuation. (Note: Hormone-based contraception alone may not be reliable when taking IMP; therefore, hormone-based contraceptives alone cannot be used by female Subjects or female partners of male Subjects to prevent pregnancy). Exclusion Criteria: Medical Criteria 1. Evidence of clinically significant (as judged by the Investigator), metabolic, gastrointestinal, cardiovascular, musculoskeletal, ophthalmological, pulmonary, neurological, psychiatric or endocrine diseases, malignancy, or other abnormalities (other than the indication being studied) including malaria. A rapid test for malaria may be carried out if indicated. 2. Karnofsky performance status score of \< 60%. 3. Poor general condition where any delay in treatment cannot be tolerated per discretion of the Investigator. 4. Clinically significant evidence of extrathoracic TB (e.g. miliary TB, abdominal TB, urogenital TB, osteoarthritic TB, TB meningitis), as judged by the Investigator. 5. History of allergy or hypersensitivity to any of the study Investigational Medicinal Products or related substances. 6. Known or suspected current alcohol and/or drug abuse (positive urine drug screen) or history thereof within the past 2 years that is, in the opinion of the Investigator, sufficient to compromise the safety and/or cooperation of the Subject. 7. For HIV infected Subjects: 1. having a CD4+ count \<100 cells/µL; 2. with an AIDS-defining opportunistic infection or malignancies (except pulmonary TB); 3. currently treated with or will need to initiate antiretroviral therapy (ART) which is not compatible with the allowed ARTs and is not considered an appropriate candidate for switching to a regimen of ARVs which is allowed as follows: * Triple nucleoside reverse transcriptase inhibitor (NRTI) based regimen consisting of zidovudine, lamivudine, and abacavir; * Nevirapine based regimen consisting of nevirapine in combination with any NRTIs; * Lopinavir/ritonavir (Aluvia™) based regimen consisting of lopinavir/ritonavir (Aluvia™) in combination with any NRTIs; * Raltegravir in combination with nucleoside reverse transcriptase inhibitors (NRTIs); 4. cannot ensure a 2 week interval between commencing IMP and the start of ART. 8. Having participated in other clinical study/ies with investigational agent/s within 8 weeks prior to trial start. 9. Significant cardiac arrhythmia requiring medication. 10. Subjects with the following at screening (per measurements and reading done by Central ECG): 1. Marked prolongation of QT/QTc interval, e.g. confirmed demonstration of QTcF (Fridericia correction) or QTcB (Bazett correction) interval \>450 ms at screening; 2. History of additional risk factors for Torsade de Pointes, e.g. heart failure, hypokalemia, family history of Long QT Syndrome; 3. Use of concomitant medications that are known to prolong the QT/QTc interval (see exclusion criteria 19); 4. Any clinically significant, in the opinion of the Investigator, ECG abnormality. 11. Females who are pregnant, breast-feeding, or planning to conceive a child during the study or within 6 months of cessation of treatment. Males planning to conceive a child during the study or within 6 months of cessation of treatment. 12. Diabetes Mellitus resulting in hospitalization in the past year. 13. Evidence of lens opacity on slit lamp ophthalmologic examination as defined by a grading of \>1+ on the AREDS2 grading system. 14. For males, any history of a clinically significant abnormality in the reproductive system. Specific Treatments 15. Previously received treatment with PA-824, bedaquiline or moxifloxacin as part of a clinical trial. 16. For the DS-TB treatment arms: treatment with any drug active against M. Tb within the 3 years prior to Day 1 (including but not limited to isoniazid, ethambutol, amikacin, bedaquiline, clofazimine, cycloserine, fluoroquinolones, rifabutin, rifampicin, streptomycin, kanamycin, para-aminosalicylic acid, rifapentine, pyrazinamide, thioacetazone, capreomycin, thioamides, metronidazole). Exceptions include the use of fluoroquinolones and metronidazole as short-term treatment (≤2 weeks) for Non-M.Tb infections. Treatment should have been discontinued at least 3 months prior to Day 1. Subjects who have previously received isoniazid prophylactically may be included in the trial as long as that treatment is/was discontinued at least 7 days prior to randomization into this trial. 17. MDR-TB Subjects may have previously been treated for DS-TB with first-line TB drugs (isoniazid, rifampicin, ethambutol, pyrazinamide and/or streptomycin) and/or received ≤7 days MDR-TB treatment, provided that treatment is/was discontinued at least 7 days prior to randomization. It should be confirmed that the MDR-TB treatment can be safely stopped and the screening period is long enough to allow for a washout period of 5 times the longest half-life of the drugs. 18. Any diseases or conditions in which the use of the standard TB drugs or any of their components is contra-indicated, including but not limited to acute gout, allergy to any TB drug, their component or to the IMP. 19. Use of any drug within 30 days prior to dosing known to prolong QTc interval (including but not limited to amiodarone, bepridil, chloroquine, chlorpromazine, cisapride, cyclobenzaprine, clarithromycin, disopyramide dofetilide, domperidone, droperidol, erythromycin, halofantrine, haloperidol, ibutilide, levomethadyl, mesoridazine, methadone, pentamidine, pimozide, procainamide, quinidine, sotalol, sparfloxacin, thioridazine). Exceptions may be made for Subjects that have received 3 days or less of one of these drugs or substances, if there has been a wash-out period before administration of IMP equivalent to at least 5 half-lives of that drug or substance. Subjects who have taken drugs with long elimination half-lives such as amiodarone should be discussed with the Sponsor. 20. Use of any drugs or substances within 30 days prior to dosing known to be strong inhibitors or inducers of cytochrome P450 enzymes (including but not limited to quinidine, tyramine, ketoconazole, fluconazole, testosterone, quinine, gestodene, metyrapone, phenelzine, doxorubicin, troleandomycin, cyclobenzaprine, erythromycin, cocaine, furafylline, cimetidine, dextromethorphan). Exceptions may be made for Subjects that have received 3 days or less of one of these drugs or substances, if there has been a wash-out period before administration of IMP equivalent to at least 5 half-lives of that drug or substance. 21. Any ARVs other than allowable ARVs detailed in exclusion criteria no. 7 above. Based on Laboratory Abnormalities: 22. Subjects with the following toxicities at screening as defined by the enhanced Division of Microbiology and Infectious Disease (DMID) adult toxicity table: 1. serum magnesium and calcium (corrected for albumin) levels outside of the laboratory's reference range 2. lipase grade 3 or greater (\>2.0 x ULN); 3. creatinine grade 2 or greater (\>1.5 x ULN); 4. hemoglobin grade 4 (\<6.5 g/dL); 5. platelets \> grade 2 (under 50x10(9) cells/L); 6. serum potassium less than the lower limit of normal for the laboratory; 7. aspartate aminotransferase (AST) grade 3 or greater (≥3.0 x ULN) to be excluded; 8. alanine aminotransferase (ALT) grade 3 or greater (≥3.0 x ULN) to be excluded; 9. alkaline phosphatase (ALP) grade 4 (\>8.0 x ULN) to be excluded, grade 3 (≥3.0 - 8.0 x ULN) must be discussed with and approved by the Sponsor Medical Monitor; 10. total bilirubin grade 3 or greater (≥2.0 x ULN, or ≥1.50 x ULN when accompanied by any increase in other liver function test) to be excluded, grade 2 (≥1.50 x ULN, or ≥1.25 x ULN when accompanied by any increase in other liver function test) must be discussed with and approved by the Sponsor Medical Monitor