Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy

Inclusion Criteria: * Clinical diagnosed as chronic nephritic syndrome * IgA nephropathy diagnosed by kidney biopsy * Aged from 18 to 65 years，male or female * Blood pressure of ≤140/90mmHg * Estimated Glomerular Filtration Rate (eGFR)≥45ml/min/1.73 m2 * 24-hour proteinuria ranged between 0.5g-3.0g * Obtaining the signed informed consent from patients Exclusion Criteria: * Secondary IgA nephropathy * Be allergic to Huangkui Capsule or Losartan potassium tablet * Taken Huangkui Capsule or ACEI or ARB in last 6 weeks * Taken the glucocorticoids, immunosuppressants or common threewingnut root and such as drugs with immunosuppressive actions in the last 12 months * Blood pressure \<90/60mmHg * Serum potassium level \> 5.5mmol / L * Serum albumin level \<30g / L * Lactation, pregnancy or plans pregnancy during the study period * Unilateral or bilateral renal artery stenosis * Combined with severe primary diseases of heart, brain, liver and hematopoietic system and so on, or other serious diseases which can affect the patient's life * Participating in another clinical study in the same period