The investigators hypothesize that using Losartan would help decrease proteinuria in controlling proteinuria in children with immunoglobulin A nephropathy.
Twenty nine patient with IgA nephropathy with proteinuria (urine protein to creatinine ratio \> 0.3 mg/mg) were included in the study. All patients had received losartan treatment for 24 weeks. Changes in blood pressure, proteinuria, renal function, and biochemical parameters were prospectively evaluated before and at 4 weeks and 24 weeks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
37
Dose of Losartan : 0.7mg/kg once daily.
Seoul National University Children's Hospital
Seoul, South Korea
the change in urinary protein-creatinine ratio from baseline to the end of study
Change in urinary protein excretion, determined as urinary protein-creatinine ratio compared to baseline, after 24 weeks of treatment.
Time frame: 24weeks
the change in urinary albumin-creatinine ratio from baseline to the end of study
Change in urinary albumin-creatinine ratio compared to baseline, after 24 weeks of treatment.
Time frame: 24 weeks
the proportion of patients wifh more than 50% decrease of urinary protein-creatinine ratio
Number of patients with wifh more than 50% decrease of urinary protein-creatinine ratio compared to baseline, after 24 weeks of treatment.
Time frame: 24 weeks
the proportion of patients wifh urinary protein-creatinine ratio < 0.2 at the end of study
Number of patients wifh urinary protein-creatinine ratio \< 0.2 after 24 weeks of treatment.
Time frame: 24 weeks
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