The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities. It was hypothesized that ICT facilitated, game blended cognitive and/or physical exercise improves global cognition when compared to control groups; moreover, these improvements may be manifested by brain activity changes; we explored the impact of potential moderators on combined exercise-induced cognitive benefits, as well as, individual/separate training schemes.
The study was conducted in the Thessaloniki (Greece), in various centers. It was part of the Long Lasting Memories (LLM) project (www.longlastingmemories.eu), which was funded by the European Commission (Information and Communication Technologies Policy Support Program (ICT-PSP) for a three year period (2009-2012). It used a pre-post-test design with the between-participant factor group \[intervention(s) vs. passive and/or active control\]. Post-test was conducted within 2 weeks after completion of the exercise period. Interventions were carried out in Thessaloniki (Greece) within day care centers, hospitals, senior care centers, a memory outpatient center, local parishes, and at participants' homes. Centers had to provide 8 exercise weeks, with a frequency of at least 2 physical and 3 cognitive exercise sessions per week, resulting in at least 16 physical and 24 cognitive exercise sessions in total. A similar trial was registered with Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02267499
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
581
LLM training Participants use the FitForAll exergaming computer platform as the physical training component (PTC); Participants use the language adapted Version of the BrainFitness Program as the cognitive training component (CTC)
PTC training Participants use the FitForAll exergaming computer platform as the physical training component (PTC)
CTC training Participants use the language adapted Version of the BrainFitness Program as the cognitive training component (CTC)
Active cognitive training by use of the VideoGrade software by AUTH.
overall cognition
Greek versions of the California Verbal Learning Test \[CVLT\], the Digit Span Test and the Trail Making Test \[TMT\] were used to assess cognitive outcomes
Time frame: 2 Monhths
physical fitness
Physical capacity was measured by means of the Senior Fitness Test
Time frame: 2 months / 6+2 months / 12+2 months
Episodic memory
calculated by averaging z-standardized sub-scores of the three cognitive tests (primary outcome)
Time frame: 2 months / 6+2 months / 12+2 months
working memory
calculated by averaging z-standardized sub-scores of the three cognitive tests (primary outcome)
Time frame: 2 months / 6+2 months / 12+2 months
executive function
calculated by averaging z-standardized sub-scores of the three cognitive tests (primary outcome)
Time frame: 2 months / 6+2 months / 12+2 months
Quality of Life
WHOQoL
Time frame: 2 months / 6+2 months / 12+2 months
Instrumental Activities of daily living
IADL
Time frame: 2 months / 6+2 months / 12+2 months
Depressive symptoms
GDS
Time frame: 2 months / 6+2 months / 12+2 months
Brain function
changes in abnormal brain waves that correlate with mild cognitive decline and dementia as measured by EEG and/or ERPs; changes in resting state networks; localisation of brain region activations/de-activations
Time frame: 2 months
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