TDF and LdT in Immune-tolerant CHB Patients Awaiting Assisted Reproduction

Inclusion Criteria: * aged 18-45 years old with artificial reproductive needs * Liver function (ALT) \<40U/L for male and \<30 for female * HBV-DNA\> 10e+5 * HBVeAg + * History\> 0.5 years Exclusion Criteria: * Cirrhosis * Combined with other liver diseases such as autoimmune liver disease, alcoholic liver disease, fatty liver * Liver or other parts of malignancies * Bilirubin\> 17.1 * GGT\> 2ULN * Liver transplant patients * combined HCV, HDV, HIV infection * A history of anti-HBV drug resistance * History of habitual abortion * previous fetal malformation history * CRP\> 3.0ng / ml * Uncontrolled hypertension * Proteinuria or Calculated creatinine clearance \< 70 mL/min * Heart failure or acute coronary syndrome * Coagulopathy * Drug or alcohol addiction * Hyperlipidemia LDL\> 4.6 or TG\> 2.0 * Alphafetoprotein \> 50 ng/mL * Received interferon (pegylated or not) therapy within 6 months of the screening visit * Evidence of hepatocellular carcinoma * Received solid organ or bone marrow transplantation * Was currently receiving therapy with immunomodulators (eg, corticosteroids, etc.), investigational agents, nephrotoxic agents, or agents * Known hypersensitivity to the study drugs, the metabolites, or formulation excipients