Opioids are commonly used to treat migraine in North American Emergency Departments. We are comparing efficacy and adverse events of hydromorphone, an opioid, to that of prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine will be combined with diphenhydramine to prevent adverse events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
127
Montefiore Medical Center--Einstein
The Bronx, New York, United States
Number of Participants With Sustained Headache Relief Assessed by Self-evaluation
Sustained headache relief is defined as achieving a headache level of "mild" or "none" within two hours and maintaining a level of "mild" or "none" for 48 hours, without use of addition medication. Patient self-evaluated pain level is solicited every half hour for two hours in the Emergency Department and then by telephone 48 hours after medication administration.
Time frame: up to 2 hours in Emergency Department, 48 hours after discharge from Emergency Department
Number of Participants Needing Rescue Medication as Assessed by Questionnaire
Data collected by telephone. Patients were asked if they needed additional medication after discharge in order to reduce level of pain. This additional medication is considered rescue medication.
Time frame: 48 hours after discharge from Emergency Department
Number of Participants Who Achieved Short Term Headache Relief, Assessed by Telphone Questionnaire
Participants were asked to make evaluation of pain status since discharge. Those achieving headache level "mild" or "none" for 1 hour are considered to achieve short term headache relief.
Time frame: 48 hours after discharge from Emergency Department
Number of Participants Who Achieved Short Term Headache Freedom; Assessed by Telephone Questionnaire
Participants were asked to evaluate pain status since discharge. Participants who achieved total headache freedom for at least 1 hour are considered to achieve short term headache relief.
Time frame: 48 hours after discharge from Emergency Department
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