Naproxen on Tooth Sensitivity Caused by In-office Bleaching

Universidade Federal de Sergipe50 enrolled

Overview

This study aims to evaluate the effects of prior use of non-steroidal anti-inflammatory Naproxen on risk and level of tooth sensitivity caused by in-office bleaching procedures.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Toothache Tooth Bleaching

Interventions

NaproxenDRUG

The patient will receive a single-dose of Naproxen (500 mg) one hour before the bleaching procedure.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * At least 18 years old patients of both genders presenting good general/oral health; * All maxillary anterior teeth presenting shade equal or darker than 2M2 at Vita bleachguide guide (Vita-Zahnfabrik, Germany); * Signed the form accepting to participate of this study. Exclusion Criteria: * Presence of caries lesions, restorations and/or endodontic treatment at any maxillary anterior teeth. * Undergone tooth-whitening procedures; * Pregnant/lactating; * Presence of periodontal diseases; * Presence of severe tooth discoloration by tetracycline stains or fluorosis; * Any kind of medicine, bruxism habits or any other pathology that can cause sensitivity (such as recession, dentin exposure); * Continuous use of drugs with anti-inflammatory actions; * Presence of tooth hypersensitivity at baseline measurement; * Any known adverse effects caused by Naproxen; * Non-attendance to any session of evaluation or bleaching.

Locations (1)

Universidade Federal de Sergipe

Aracaju, Sergipe, Brazil

Outcomes

Primary Outcomes

Risk to Tooth sensitivity - during procedure

The tooth sensitivity will be evaluated using a 5-point Verbal rating scale (VRS), where 0 = none, 1 = mild, 2 = moderate, 3 = considerable and 4 = severe. Score different from 0 will determine presence of sensitivity. The risk of tooth sensitivity will be determined by relative risk assessed by ratio between absolute risk of experimental condition by those observed in control. The 95% confidence interval will be calculated.

Time frame: During the bleaching procedure

Secondary Outcomes

Level of tooth sensitivity - during procedure

The tooth sensitivity will be evaluated using a 5-point Verbal rating scale (VRS), where 0 = none, 1 = mild, 2 = moderate, 3 = considerable and 4 = severe.

Time frame: During the bleaching procedure

Risk of tooth sensitivity - after procedure

Time frame: 24 hours after bleaching prcedure

Level of tooth sensitivity - after procedure

The tooth sensitivity will be evaluated using a 5-point Verbal rating scale (VRS), where 0 = none, 1 = mild, 2 = moderate, 3 = considerable and 4 = severe.

Time frame: 24 hours after bleaching prcedure

Data from ClinicalTrials.gov

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