Rifaximin Use in Severe Alcoholic Hepatitis

Inclusion Criteria: * Heavy alcohol drinking within 3 months (Over 40 g/day) * Maddrey's discriminant function ≥ 32 * AST/ALT ration ≥ 2 * Bilirubin level ≥ 5mg/dL * Any one of the following additional criteria : hepatic encephalopathy, enlarged, tender liver, or peripheral leucocytosis * Age : 19-75 * Jaundice within 3 months Exclusion Criteria: * Other causes of chronic liver disease (HBV, HCV, or autoimmune hepatitis) * Antibiotics or probiotics use within 8 weeks * Drug induced hepatotoxicity * Acute viral hepatitis (HAV or HEV) * Hepatic abscess or cholagitis * Hepatocellular carcinoma of modified UICC stage II, III or IV * Malignant tumor other than HCC * Pregnancy * Severe chronic extrahepatic disease * Type I hepatorenal syndrome * Hepatic encephalopathy grade II or IV * Severe infection