Early Simplified: A Trial to Compare the Efficacy of Standard of Care Combination Antiretroviral Therapy With a Simplified Dolutegravir Monotherapy in Patients With a Primary HIV-1 Infection

Inclusion Criteria: * Informed Consent as documented by signature, * All patients ≥18 years with a documented primary HIV-infection undergoing standard of care cART (i.e., one active drug from the class of either the PIs, or the NNRTIs, or the INSTIs, in combination with two active drugs from the class of NRTIs) with no previous structured treatment interruption and with a suppressed viral load (defined as 50 copies/ml) during the previous 48 weeks, * Participant of the Swiss HIV Cohort Study Exclusion Criteria: * Patients not willing to sign the informed consent form, * Presence of ≥1 major integrase inhibitor resistance associated mutation according to the Sanford algorithm1, * History of ≥2 consecutive plasma viremia levels \>400 copies/ml at least two weeks apart, * Ongoing (i.e., replicating) hepatitis B virus infection, * Hemoglobin \< 10 g/dl (men) and \< 9 g/dl (women) at the time of enrolment, * Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product, * Women who are pregnant or breast feeding, * Intention to become pregnant during the course of the study, * Lack of safe contraception, * Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.), * Known or suspected non-compliance, drug or alcohol abuse, * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, * Participation in another study with investigational drug within the 30 days preceding and during the present study, * Previous enrolment into the current study, * Enrolment of the investigator, his/her family members, employees and other dependent persons.