The purpose of this study is to determine if rifaximin reduces serum trimethylamine-N-oxide (TMAO) levels in patients with end-stage renal disease.
Study participants will undergo 3 study visits: baseline, day 7 (immediately post-therapy), day 21 (2 weeks post-therapy). All participants will provide blood and stool samples at each visit.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
One 550 mg tablet taken orally two times a day.
University of Kansas Medical Center
Kansas City, Kansas, United States
Westwood Dialysis Center
Westwood, Kansas, United States
Change in serum TMAO levels
Time frame: Change from Baseline to Day 7
Change in serum TMAO levels
Time frame: Change from Baseline to Day 21
Change in fecal bacterial species
Time frame: Change from Baseline to Day 7
Change in fecal bacterial colony numbers
Time frame: Change from Baseline to Day 7
Change in fecal bacterial species
Time frame: Change from Baseline to Day 21
Change in fecal bacterial colony numbers
Time frame: Change from Baseline to Day 21
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