Bread is the most common grain product in the world, with consumption surpassing 3 billion individuals per year. Sourdough whole-grain bread is considered a healthy alternative to white, refined-wheat bread. This cross-over study will test the effect of consumption of sourdough bread compared to white bread following a short dietary intervention period (one week) on multiple clinical parameters and gut microbiota.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Participants will be given sourdough bread to consume instead of other wheat products. 145g will be consumed every morning in addition to ad libitum consumption throughout the day (matched between first and second intervention periods)
Participants will be given white bread to consume instead of other wheat products. 110g will be consumed every morning in addition to ad libitum consumption throughout the day (matched between first and second intervention periods)
Weizmann Institute of Science
Rehovot, Israel
Department of Gastroentherology
Tel Aviv, Israel
Changes to glycemic control
Measured as response to an Oral Glucose Tolerance Test (OGTT; mg/dl\*h).
Time frame: One week
Changes to glycemic control
Measured as blood glucose levels at wake-up (mg/dl).
Time frame: One week
Changes to total cholesterol levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to HDL cholesterol levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to LDL cholesterol levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to triglycerides levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to C-Reactive Protein (CRP) levels (mg/l)
Measured by a blood test.
Time frame: One week
Changes to weight (Kg.)
Time frame: One week
Changes to Basal Metabolic Rate (BMR; J)
Time frame: One week
Changes to blood pressure (mmHg)
Time frame: One week
Changes to Alanine Transaminase (ALT) levels (IU/l)
Measured by a blood test.
Time frame: One week
Changes to Aspartate Transaminase (AST) levels (IU/I)
Measured by a blood test.
Time frame: One week
Changes to Gamma-Glutamyl Transpeptidase (GGT) levels (IU/l)
Measured by a blood test.
Time frame: One week
Changes to Creatinine levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to Magnesium levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to Calcium levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to Iron levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to Urea levels (mg/dl)
Measured by a blood test.
Time frame: One week
Changes to Lactate Dehydrogenase (LDH) levels
Measured by a blood test (IU/l)
Time frame: One week
Changes to Thyroid Stimulating Hormone (TSH)
Measured by a blood test (mIU/ml)
Time frame: One week D
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.