The purpose of this study is to determine whether febuxostat and benzbromarone could protect renal function in chinese, and which one could be better.
Chronic kidney disease patients with hyperuricemia and glomerular filtration rate (GFR) 20-60 ml/min were treated by febuxostat or benzbromarone. Follow up the changes of serum uric acid, serum creatinine and GFR levels. Compare the effects on renal function of these two drugs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
800
It acts as an inhibitor of xanthine oxidase, thus lowering urate concentrations in the body
It is structurally related to the antiarrhythmic amiodarone, and it is a uricosuric agent and non-competitive inhibitor of xanthine oxidase
Department of Nephrology & Rheumatology, Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China
serum creatinine, estimated glomerular filtration rate (eGFR)
eGFR will be estimated by CKD-EPI equation, which is most widely used recently in the world. eGFR will be calculated according to serum creatinine, age, gender and race.
Time frame: up to 12th months
urine protein
Time frame: 6th months, 12th months
adverse drug reaction
Time frame: 1st month, 2nd months, 3rd months, 6th months, 9th months, 12th months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.