Expanded Access With ABT-888 (Veliparib) to Treat Metastatic Breast Cancer

1. Inclusion Criteria Roll-over patients: This protocol allows for the inclusion of 3 patients actively participating in protocol 7161 who are expected to continue to benefit from uninterrupted dosing of veliparib monotherapy. For newly enrolled patients the following criteria should be satisfied within 28 days of Day 1 of protocol treatment. Results from routine clinical evaluations within 28 days prior to enrollment may be used to determine eligibility: * Locally recurrent and not amenable to surgical therapy, and/or metastatic breast cancer * Confirmed HER2-, BRCA1 or BRCA2 mutation-associated breast cancer or sporadic triple negative breast cancer. * No opportunity to receive veliparib under a current clinical trial. * Patients may have had any number of prior lines of chemotherapy, endocrine therapy, immunologic, or biologic regimens for metastatic breast cancer. * Patients receiving bisphosphonates, denosumab or LHRH-agonists are eligible. * 18 years and older. * Performance status \> 60% on the Karnofsky scale (ECOG \< 2). * Adequate hematologic, renal and hepatic function as follows: * Bone Marrow: Absolute neutrophil count (ANC) \> 1,500/mm3 (1.5 × 109/L); Platelets \> 100,000/mm3 (100 × 109/L); Hemoglobin \> 9.0 g/dL * Serum creatinine \< 1.5 × upper normal limit of institution's normal range OR creatinine clearance \> 50 mL/min/1.73m2 for patients with creatinine levels above institutional normal; * Hepatic function: AST and/or ALT \< 2.5 × the upper normal limit of institution's normal range. o For patients with liver metastases, AST and/or ALT \< 5 × the upper normal limit of institution's normal range; * Bilirubin \< 1.5 × the upper normal limit of institution's normal range; o Patients with Gilbert's Syndrome may have a bilirubin \> 1.5 × the upper normal limit of institution's normal range. * Women of childbearing potential must agree to use adequate contraception (one of the following listed below) prior to protocol entry, for the duration of protocol participation and for 90 days following completion of therapy. Women of childbearing potential must have a negative serum pregnancy test within 21 days prior to initiation of treatment and/or be confirmed as having postmenopausal status. Criteria for determining menopause include any of the following: prior bilateral oopherectomy; age \> 60 years; age \< 60 years and amenorrheic for at least 12 months in the absence of chemotherapy, endocrine therapy, or ovarian suppression and FSH and estradiol in the postmenopausal range. * Total abstinence from sexual intercourse (minimum one complete menstrual cycle); * Vasectomized partner of female patients; * Hormonal contraceptives (oral, parenteral or transdermal) for at least 3 months prior to study drug administration; * Double-barrier method (condoms, contraceptive sponge, diaphragm or vaginal ring with spermicidal jellies or cream); * IUD (Intra-Uterine Device). * Additionally, male patients (including those who are vasectomized) whose partners are pregnant or might be pregnant must agree to use condoms for the duration of the treatment plan and for 90 days following completions of therapy. * Radiation therapy must have been completed at least 2 weeks prior to the enrollment date. * Patients with known brain metastases must have clinically controlled neurologic symptoms, defined as surgical excision and/or radiation therapy followed by 14 days of stable neurologic function prior to the first dose of study drug. * Ability to understand and the willingness to sign a written informed consent document. 2. Exclusion Criteria * Prior treatment with PARP inhibitor (excluding iniparib). Patients participating in protocol 7161 (NCI-2010-00356) are eligible. * Clinically significant and uncontrolled major medical condition(s) including but not limited to: * Active uncontrolled infection; * Symptomatic congestive heart failure; * Unstable angina pectoris or cardiac arrhythmia; * Psychiatric illness/social situation that would limit compliance with protocol requirements; * Any medical condition, which in the opinion of the investigator, places the patient at an unacceptably high risk for toxicities; * Myelodysplastic syndrome; * History of seizures within last 12 months or known neurological disorder pre-disposing to seizures * Patient is pregnant or lactating.