The Association of Omentin and Ischemic Stroke

Xi'an No.3 Hospital2,000 enrolled

Overview

This observational study aims to research whether there is a relationship between omentin and ischemic stroke on the aspects of incidence, severity, and recovery etc.

To study the possible relationship between omentin and ischemic stroke, we intend to recruit the newly found acute ischemic stroke patients and patients without any stroke history and analysis the difference of plasma omentin level and the ITLN, which is the gene symbol of omentin.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Stroke Brain Ischemia Adipokines Mutation

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For ischemic stroke group,acute clinically defined ischemic stroke * For control group, without any history of stroke Exclusion Criteria: For ischemic stroke group * Hemorrhagic Stroke * Previous Ischemic Stroke For control group * The expected life expense less than 3 years

Locations (1)

Xi'an No.3 Hospital

Xi’an, Shanxi, China

RECRUITING

Outcomes

Primary Outcomes

the odds ratio of omentin plasma concentration between cases and controls

The circulation level of omentin will be assessed in cases and controls. Then the odds ratio will be statically analysed to detect whether omentin is asociated with ischemic stroke on protein level.

Time frame: up to 3 years

the frequency difference of single nucleotide polymorphism(SNP) of omentin in the enrolled subjects

The SNP will be analysed in the recruited subjects. And the the frequency difference will be calculated to explore if any SNP is related to ischemic stroke.

Time frame: up to 3 years

Secondary Outcomes

the NIHSS assessed for functional outcome of stroke

NIHSS wil be used to assess neurological status at baseline or the point of stroke, the point of out-patient, 3 month, 6 month, 1 year, 2 year and the 3 year.

Time frame: up to 3 years

the modified Rankin Scale assessed for functional disability

Th functional disability will be assessed using the modified Rankin Scale at the time of baseline, out-patient, 3rd month, 6th month, 1st year, 2nd year and the 3rd year after enrollment.

Time frame: up to 3 years

the Barthel index assessed for functional independence in activities

The Barthel index at the point of baseline, out-patient, 3rd month, 6th month, 1st year, 2nd year and the 3rd year after enrollment will be assessed for the functional independence in activities.

Time frame: up to 3 years

the number of all cause death

The number of all cause of death will be recorded in both groups.

Time frame: up to 3 years

Central Contacts

Tian Ye, PhD

CONTACT

+86 13519131549 chhty@sina.com

Data from ClinicalTrials.gov

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