The Drug-Drug Interaction of SHR4640, Febuxostat and Colchicine in Patients With Gout

Inclusion Criteria: 1. Subject has a body mass index ≥18.5 and ≤30 kg/m2; 2. Screening sUA value ≥8mg/dl; 3. Subject has no clinically relevant abnormalities in vital signs, ECG, physical examination，imaging examination or safety laboratory values. Exclusion Criteria: 1. Subject known or suspected of being sensitive to the study drugs or its ingredient； 2. sCr\>ULN; 3. History of kidney stones or screening kidney stones by B-ultrasound； 4. History of malignancy within 5 years； 5. History of xanthinuria； 6. Donated blood（≥400ml）within 3 months prior to screening or received transfusion of blood。