The purpose of the proposed study to examine the links among stress, craving for marijuana, and marijuana reminders, or "cues". In this study, an agent called yohimbine will be used to produce stress-like responses. Yohimbine is known to cause stress response in studies of alcohol and other substance use disorders. This study intends to show it can be used to cause stress in marijuana users as well.
Part of this study will be conducted on a residential unit where participants will live for 7 nights over a 2-week period (4 consecutive nights the 1st week and 3 consecutive nights the 2nd week). During that time, participants can't leave the unit unescorted or have visitors. During the inpatient stay participants will participant in experimental sessions where they will be asked to smoke cigarettes containing either marijuana or placebo (a blank). Participants will be asked to take capsules that could contain yohimbine or placebo (blank). Participants will be asked to complete questionnaires and will have their vital signs (blood pressure, heart rate) monitored throughout each session. Participants will be asked to participate in overnight sleep recordings, a polysomnogram (PSG).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
12
Yohimbine (0mg, 20mg, or 40 mg) will be administered at 11:00am on each of the experimental sessions.
Tolan Park Medical Building
Detroit, Michigan, United States
Marijuana Craving Visual Analog Scale (VAS) (Self-report measure)
Time frame: Change is being assessed. Marijuana Craving VAS administered at baseline 0900. It will then be administered at 1000, 1030, 1100, 1200, 1220, 1245, 1300, 1315, 1345.
Marijuana Craving Questionnaire (Self-report measure)
Time frame: Change is being assessed. Marijuana Craving Quest.administered at baseline 0900. It will then be administered at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
Questionnaire of Smoking Urges (Self-report measure)
Time frame: Change is being assessed. Questionnaire is administered at baseline 0900. It will then be administered at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
Marijuana Rating Form (Self-report measure)
Time frame: Change is being assessed. Marijuana Rating Form is administered 30 minutes after each smoking episode in the sampling session.
Marijuana Withdrawal Checklist
Time frame: Change is being assessed. Questionnaire is administered every morning and evening.
Subjective Effects Scale Visual Analog Scale (VAS) (Self-report measure)
Time frame: Change is being assessed. Subjective Effects Scale administered at baseline 0900.It will then be administered at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
Positive & Negative Affect Schedule (Self-report measure)
Time frame: Change is being assessed. Questionnaire is administered at baseline 0900. It will then be administered at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
Systolic blood pressure (physiological effects)
Time frame: Change is being assessed. Systolic blood pressure measured at baseline 0900. It will then be measure at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
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Diastolic blood pressure (physiological effects)
Time frame: Change is being assessed. Diastolic blood pressure measured at baseline 0900. It will then be measure at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
Heart rate (physiological effects)
Time frame: Change is being assessed. Heart rate measured at baseline 0900. It will then be measure at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.
Core-body temperature (physiological effects)
Time frame: Change is being assessed. Core-body temperature measured at baseline 0900. It will then be measure at 1000, 1030, 1100, 1200, 1410, 1430, 1500, 1530, 1600, 1630.