Niclosamide With Etanercept in Rheumatoid Arthritis

Inclusion Criteria: * Patients with RA, as defined by the American College of Rheumatology (ACR) 1987 revised criteria or ACR/EULAR 2010, * Severly Active RA by calculating either DAS28 or SDAI or CDAI. * Patient selected are those who started etanercept for less than 3months and still active. Exclusion Criteria: * Patients on nonsteroidal anti-inflammatory drugs (NSAID) 2 days before entry into this study. or methotrexate (MTX).. * Patients with hypersensitivity or severe adverse effects to niclosamide . * Renal impairment. * Hepatic impairment. * Pregnancy or a desire to become pregnant. * Breast feeding. * Patients with Juvenile RA \[16 years old or younger\]. * Patients using other conventional disease modifying antirheumatic drugs (DMARDs). * Patients on steroid. * Patients with coexistence other connective tissue diseases or hypothyroid disease. * Patient with mild or inactive RA.