Lowering-hyperuricemia Treatment on Cardiovascular Outcomes in Peritoneal Dialysis Patients

Inclusion Criteria: * 1.Subjects who are able to understand and have voluntarily signed the informed consent form (ICF) * 18-70 years old at the time of randomization * Subjects on PD for more than 3 months. * Subjects have hyperuricemia, women: 6mg/dl(360μmol/L) \<serum uric acid (sUA)\<12mg/dl(720μmol/L); men: 7mg/dl(420μmol/L)\<sUA\<12mg/dl(720μmol/L). Exclusion Criteria: * 1.Subjects has history of gout * Subjects who have a myocardial infarction, unstable angina,cardiovascular reconstructive surgery (such as a stent or bypass surgery), cerebrovascular accident 12 weeks prior to randomization, or plan cardiovascular reconstructive surgery during the trial * Subjects who have New York stage IV heart failure occurs 4 weeks prior to the screening * Subjects who have previously received renal transplantation and are currently prescribed immunosuppressive therapy * Subjects who have severe liver disease, such as acute hepatitis, chronic active hepatitis, cirrhosis * Subjects who have alanine aminotransferase (ALT) greater than 2 folds of the upper limited of normal or total bilirubin greater than 1.5 folds of upper limited of normal * Subjects who have severe infections 4 weeks prior to the screening, such as pneumonia and peritoneal dialysis-related peritonitis; * Subjects who have a major surgery 12 weeks prior to screening or not yet fully recovered from the surgery * Subjects who have a malignancy * Subjects who report a history of illicit drug use or a regular or daily alcohol consumption of≥4 alcoholic drinks per day in the 2 years before Screening * Subjects who are allergic to Febuxostat * Subjects who are enrolled in other clinical studies within 4 weeks or currently at randomization * Subjects who are currently taking mercaptopurine, azathioprine, vidarabine, didanosine * Subjects who are taking losartan, fenofibrate, thiazide diuretics or loop diuretics within 4 weeks at randomization * Subjects who require long-term use of steroids (prednisone \<30mg / d, or equivalent amount of other steroids and the use of \<2 weeks can be enrolled) * Subjects who require long-term use of salicylic acid drugs except low-dose aspirin * Fertility, lactation patients unwilling or unable to contraception