Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer

Inclusion Criteria: * Women age ≥ 18 years * Eastern Cooperative Oncology Group performance status 0-2 (Karnofsky \>60%). * Patients with metastatic breast cancer. * HER2 (human epidermal growth factor receptor 2)-positive breast cancer prospectively determined on the primary tumor by a local pathology laboratory and defined as: Immunohistochemistry (IHC) score of 3+ and/or positive by ISH (defined by In Situ Hybridization ratio of ≥ 2.0 for the number of HER2 gene copies to the number of chromosome 17 copies). Both IHC and ISH assays will be performed; however, only one positive result is required for eligibility. * Estrogen/progesterone receptor positive OR negative disease allowed. * Patients must have measurable disease per the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1. * Patients that have failed at least one anti-HER2 therapy in the metastatic setting. * Patients must have normal organ and marrow function as defined below: * absolute neutrophil count ≥1,500/mL * platelets ≥100,000/mL * total bilirubin ≤ institutional upper limit of normal (ULN) * aspartate aminotransferase (AST)/alanine aminotransferase (ALT) 5 ≤ X institutional ULN * creatinine ≤ institutional ULN OR creatinine clearance ≥ 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal. * Baseline left ventricular ejection fraction (LVEF) ≥ 50% measured by echocardiogram (preferred) or multigated acquisition (MUGA) scans. * Willing and able to comply with the requirements of the protocol. * Patient is able to take oral medication. * Signed informed consent. * Female patients of childbearing potential must be willing to use one highly effective form of hormonal contraception or two effective forms of nonhormonal contraception. * Contraception must continue for the duration of study treatment and for 7 months after the last dose of study treatment. The above contraception is not a requirement in the case of any of the following: * The patient, or partner of the patient, is surgically sterilized. * The female patient is \>45 years of age and is postmenopausal (has not menstruated for at least 12 consecutive months * The patient truly abstains from sexual activity and when this is the preferred option to avoid conception and contraception and/or usual lifestyle of the patient. Exclusion Criteria: * Metastatic breast cancer patients who are HER2 positive and have NOT progressed on at least one prior HER2-targeted therapies for metastatic disease * Patients who have not recovered from CTCAE, v. 4.03 grade 2 or higher toxicities of prior therapy to the point that they would be appropriate for re-dosing will be ineligible for study treatment. Subjects receiving weekly therapy must have a washout period from prior chemotherapy of as least one week. Washout period for chemotherapy administered every 2, 3, or 4 weeks will be 2, 3, and 4 weeks respectively, provided subject has recovered from toxicities of prior therapy such that retreatment is appropriate. * Patients must be at least two weeks from prior RT * Patients must have a one-week washout period from prior hormonal therapy (e.g. testosterone, estrogen, progestin, gonadotropin-releasing hormone antagonist). * Patient has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Note: Patients with previously treated brain metastases may participate provided they are stable (without evidence of progression by imaging \[using the identical imaging modality for each assessment, either MRI or CT scan\] for at least 4 weeks prior to the first dose of study treatment and any neurologic symptoms have returned to baseline), have no evidence of new or enlarging brain metastases, and have not been using steroids for at least 7 days prior to study treatment. Carcinomatous meningitis precludes a patient from study participation regardless of clinical stability. No concurrent anti-cancer treatment of any type * Patients with known germline BRCA 1 or BRCA 2 mutations * Patient has undergone prior treatment with a known poly(ADP-ribose) polymerase (PARP) inhibitor. * Prior treatment of a total doxorubicin \>360 mg/m2 (or equivalent) * Patient has known active hepatitis B (eg, hepatitis B surface antigen \[HBsAg\] reactive) or hepatitis C (eg, hepatitis C virus ribonucleic acid \[HCV RNA\] \[qualitative\] is detected). * Patient has a known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies). * Chronic immunosuppressive therapies including systemic corticosteroids or concurrent short-term use of immunosuppressive therapies is not allowed. Short- term corticosteroid use must be discontinued at least 2 weeks prior to study treatment. * Patients with known grade 2 or greater allergic reactions attributed to compounds of similar chemical or biological composition to niraparib are ineligible for study enrollment. * Patients with known grade 2 or greater allergic reactions attributed to compounds of similar chemical or biological composition to herceptin are ineligible for study enrollment. * Patient is pregnant or breastfeeding, or expecting to conceive children within the projected duration of the study, starting with the screening visit through 7 months after the last dose of study treatment. * History of non-breast malignancies within the 5 years prior to study entry, except for the following: * Carcinoma in situ (CIS) of the cervix * CIS of the colon * Melanoma in situ * Basal cell and squamous cell carcinomas of the skin * Patient is considered a poor medical risk due to a serious, uncontrolled medical disorder, nonmalignant systemic disease or active infection that requires systemic therapy. Specific examples include, but are not limited to, active, non-infectious pneumonitis; uncontrolled major seizure disorder; unstable spinal cord compression; superior vena cava syndrome; or any psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study (including obtaining informed consent). * Cardiopulmonary dysfunction as defined by any of the following prior to randomization: * History of National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE; Version 4.0) Grade ≥3 symptomatic congestive heart failure (CHF) or New York Heart Association (NYHA) criteria Class ≥ II * Angina pectoris requiring anti-angina medication, serious cardiac arrhythmia not controlled by adequate medication, severe conduction abnormality, or clinically significant valvular disease * High-risk uncontrolled arrhythmias (i.e. atrial tachycardia with a heart rate \>100/min at rest, significant ventricular arrhythmia \[ventricular tachycardia\], or higher-grade atrioventricular \[AV\]-block \[second degree AV-block Type 2 \[Mobitz 2\] or third degree AV-block\]) * Significant symptoms (Grade ≥2) relating to left ventricular dysfunction, cardiac arrhythmia, or cardiac ischemia * Myocardial infarction within 12 months prior to randomization * Uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>100 mmHg) * Evidence of transmural infarction on ECG * Heart-rate corrected QT interval (QTc) prolongation \>470 msec at screening. * Requirement for oxygen therapy