The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
70
administration of losartan (50 mg) (oral)
administration of placebo (oral)
University of Electronic Science and Technology of China
Chengdu, Sichuan, China
RECRUITINGLosartan effects on neural activity during fear extinction
Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.
Time frame: 1 hour
Losartan effects on skin conductance responses during fear extinction
Effects of treatment will be evaluated by comparing extinction-related skin conductance responses between the active treatment and the placebo group.
Time frame: 1 hour
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