Effect of ARNI in Patients With Persistent AF and Enlarged Left Atrium After Catheter Ablation

Inclusion Criteria: 1. Patients with persistent atrial fibrillation undergoing catheter ablation within 2 weeks. 2. ≥18 and ≤75 years of age. 3. Left atrium diameter（LAD）≥35mm, With or without right atrium diameter（RAD）≥40mm，diagnosed by Echocardiographic. 4. patient who are mentally and linguistically able to understand the aim of the trial and to show sufficient compliance in following the trial protocol. 5. Patients receiving ACE inhibitors (ACEI), angiotensin receptor blockers (ARB) and/or a beta blockers must be on a stable dose of these medications stable for the 1 month period prior to Visit. 6. Patients with a controlled systolic BP, defined as a target systolic BP less than 140 mm Hg; participants with BP up to and including 160 mmHg are eligible for enrollment if they are on three or more medications to control BP at randomization. 7. Patients must have an eGFR ≥ 30 ml/min/1.73 m2 at Visit 1 (calculated by the Modification of Diet in Renal Disease formula). 8. Patients with a potassium ≤5.2 mmol/l at Visit 1. Exclusion Criteria: 1. Patients with prosthetic valves. 2. Any previous LA suigery. 3. Acute coronary syndrome (including MI), cardiac surgery, other major CV surgery within 3 months , or urgent percutaneous coronary intervention within 3 months or and elective PCI within 30 days prior to entry. 4. Presence of hemodynamically significant mitral and /or aortic valve disease. 5. Presence of hemodynamically significant obstructive lesions of left ventricular outflow tract, including aortic stenosis. 6. Current acute decompensated HF requiring therapy. 7. Allergic to drugs or active ingredients (shakuba, valsartan) or any excipients。 8. Patients with previous history of angioedema associated with ACEI or ARB treatment. 9. Patient with hereditary or idiopathic angioedema. 10. patient with severe liver damage, biliary cirrhosis and cholestasis. 11. Patient with Renal artery stenosis.