Treatment of Melasma Using Q-switched Nd: YAG Laser and Fractional CO2 Laser Separately and in Combination

Kasr El Aini Hospital30 enrolled

Overview

* All participants will be divided into 2 groups : Group A \& Group B. * Group A will be subjected to 3 consecutive sessions of Q-switched 1,064 nm Nd: YAG laser to one side of the face \& fractional co2 laser to the other side of the face with one month interval between sessions. * Group B will be subjected also to 3 consecutive sessions of Q-switched 1,064 nm Nd: YAG laser to one side of the face \& an additional fractional co2 laser to the other side of the face using the above mentioned parameters with one month interval between sessions. * Response to treatment will be assessed using the Melanin Index (MI) score, Melasma Area and Severity Index (MASI) score, spectrophotometer ( Derma catch, colorix, Neuchatel, Switzerland ) and a subjective self-assessment method.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Melasma

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * melasma patients above 18 years Exclusion Criteria: * Pregnancy. * Usage of chemical peeling 1 month prior to the study. * Isotretinoin intake 6 months prior to the study. * Any laser procedure related to melasma lesions 1 month prior to the study. * Active herpetic lesions. * Any concurrent active skin disease within the treated area. * Photosensitive skin conditions such as systemic lupus erythematous. * History of delayed wound healing. * Keloid formation. * Bleeding diathesis. * Medical conditions such as diabetes mellitus \& autoimmune diseases.

Outcomes

Primary Outcomes

Modified Melasma Area and Severity index change.

Evaluate the efficacy of Q-switched 1,064nm Nd: YAG \& fractional Co2 laser in the treatment of melasma by comparing the results through measuring modified MASI score before treatment and after treatment and follow-p period.