Integrative Sequencing In Germline and Hereditary Tumours

Inclusion Criteria: 1. Patients must be ≥18 years of age 2. All patients and enrolled family members must have a signed and dated informed consent form All individuals at risk of a hereditary cancer syndrome without a known germline mutation from clinical genetic testing, will be eligible for this study. This includes: 1. Individuals with multiple primary malignancies 2. Families with a strong family history of cancer suggestive of a hereditary cancer syndrome 3. Young individuals with cancer (10 years earlier than the age of onset of sporadic cases) and no identified gene mutation 4. Rare cancer histologies Individuals with an identified germline mutation will also be eligible for this study, if there are discordant family members suggesting additional genetic factors contributing to the variable familial phenotype. For example, a family composed of mutation carriers severely affected with cancers, and carriers unaffected with cancer. Exclusion Criteria: None.