Rifaximin in Patients With Diabetic Gastroparesis

Inclusion Criteria * Men and women adult patients, aged 18-75, with diabetic gastroparesis * Diagnosis of diabetic gastroparesis will have been made previously using a combination of symptoms (e.g., nausea, vomiting, bloating, early satiety, abdominal pain), the absence of mechanical obstruction, and delayed gastric emptying using a 4-hour, solid phase scintigraphic study (GES; \> 20% remaining at 4 hours) Exclusion Criteria * Prior surgery to the stomach or esophagus * Known mechanical obstruction of the GI tract * Current or recent (\< 4 weeks) use of opioids * Current/active use of cannabis * Current or recent (\< 4 weeks) use of antibiotics * Current or recent use of antifungal agents (\< 4 weeks) * Prior treatment with rifaximin (\< 1 year) * Uncontrolled diabetes with a HgbA1c \> 12 * Severe uncontrolled or untreated anxiety or depression.