The quality of recovery in patients who were reversed neuromuscular blockade by using Sumamadex and Neostigmine in laparoscopic cholecystectomy was compared through the QoR(Quality of Recovery)-15 questionnaire.
Quality of Recovery questionnaire includes five details (Emotional status, Physical comfort, Physiological support, Physical independece, Pain), and is a proven method of reliability, consistency and validity for evaluating recovery from surgery and anesthesia. After laparoscopic cholecystectomy, patients experience various discomforts such as pain, nausea, vomiting, and placebo due to general anesthesia. Neostigmine has side effects such as crampy abdominal pain, nausea and vomiting. In addition, residual neuromuscular blockade was higher in neostigmine compared with sugammadex. Although sugammadex expected to improve patient's recovery, it is still controversial that sugammadex contributes to clinically meaningfull difference compared with neostigmine. Therefore, the aim of our study is comparison of quality of recovery through QoR-15 questionnaire in patients who were reversed neuromuscular blockade by using sugammadex and neostigmine in laparoscopic cholecystectomy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
77
sugammadex 2mg/kg or 4mg/kg according to Train-of-four count (TOF 0 : 4mg/kg, TOF 1-4 : 2mg/kg)
with glycopyrrolate 0.4mg, neostigmine 0.02mg/kg or 0.04mg/kg or 0.05mg/kg according to Train-of-four count (TOF 0 : wait until TOF 2, TOF2-3: 0.05mg/kg, TOF4: 0.04mg/kg)
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Quality of Recovery(QoR)-15 questionnaire score
the difference of Quality of Recovery(QoR)-15 score between preoperative and postoperative 1 and 2 days (minimum value : 0, maximum value : 150, the higher the score, the better the result)
Time frame: preoperative 1 days to postoperative 2 days
recovery time
from injection of sugammadex or neostigmien to extubation and confirm of adequate spontaneous breathing
Time frame: perioperative - until 48hours
PACU(post-anesthesia care unit) stay time
from entry of PACU to go general ward
Time frame: perioperative - until 48hours
postoperative pain score
postoperative pain score measured by 11-point NRS(numerical rating scale) score (minimum : 0, maximum : 11, the lower the score, the lesser pain)
Time frame: at postoperative 30minutes, 6hours, 24hours
the incidence of administration of postoperative rescue drug
administration of analgesic drug and anti-emetic drug for postoperative management
Time frame: perioperative - until 72hours
hospital stay
days of hospital stay
Time frame: preoperative - until discharge (usually 48 hours to 72hours)
urinary retention
residual urine \> 300ml diagnosed by bladder ultrasonography
Time frame: postoperative - until discharge (usually 48 hours to 72hours)
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