The purpose of this research is to identify whether or not Angiotensin Receptor Blockers (ARB) can halt the progression to respiratory failure requiring transfer into the intensive care unit (ICU), as well as halt mechanical ventilation in subjects with mild to moderate hypoxia due to the corona virus that causes COVID-19. Based on previous animal studies, the researchers hypothesize that the addition of an ARB is beneficial in abating acute lung injury in subjects in early stages of SARS-CoV-2 viral induced hypoxia.
This is an investigator initiated, open label, multicenter, two arm, randomized study to compare the impact of adding an ARB to the Standard of Care (SOC) to the SOC without an ARB. Randomization ratio will be 1:1. The goal of this study is to identify whether or not ARBs have an impact on inhibiting the progression to respiratory failure requiring mechanical ventilation in patients with mild to moderate hypoxia in the setting of COVID-19. The addition of an ARB to the standard of care treatment for these patients may be beneficial in abating acute lung injury in patients in early stages of SARS-CoV-2 induced hypoxia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
31
Standard of care plus the starting dose of losartan 12.5mg (investigator has option to increase dose on days 2-10 based on tolerance of SBP) of losartan taken twice daily for up to 10 days. Upon the treating clinician's discretion, losartan may be continued beyond 10 days for non-COVID-19 indications.
Sharp Grossmont Hospital
La Mesa, California, United States
Sharp Chula Vista Medical Center
San Diego, California, United States
Sharp Memorial Hospital
San Diego, California, United States
Mechanical Ventilation
Number of subjects requiring transfer into ICU for mechanical ventilation due to respiratory failure
Time frame: from date of patient admission to date of patient discharge or date of death, whichever came first, assessed up to 45 days
ICU Transfer
Number of subjects transferred from non-ICU bed to an ICU bed
Time frame: from date of patient admission to date of patient discharge or date of death, whichever came first, assessed up to 45 days
Oxygen Therapy
Mean number of liters of oxygen consumed
Time frame: from date of patient admission to date of patient discharge or date of death, whichever came first, assessed up to 45 days
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