The primary aim of the work is to compare the efficacy of Sugammadex and neostigmine in reversing rocuronium-induced muscle relaxation to reach complete recovery of neuromuscular block (TOF ratio≥ 0.9) in preterm neonates. The secondary aim is to evaluate the safety of using Sugammadex in preterm neonates and to detect any complications that may occur in this age group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
give 2 mg/ kg as muscle reversal drug in premature infants
give 0.02 mg/ kg atropine and 0.05 mg/kg neostigmine IV. as muscle reversal drug in premature infants
Alexandria university
Alexandria, Egypt
RECRUITINGAssessment of reversal
Reversal time which is defined as time in seconds from the start of administration of sugammadex or neostigmine to recovery of TOF ratio to 0.9
Time frame: immediately after the surgery
Evaluation of recovery
Time for modified Aldrete score to reach 10
Time frame: immediately after the surgery
number of patients with Complications
any complication during recovery will be noted
Time frame: immediately after the surgery
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